More Buying Choices $26.39 (6 new offers) Comfort Zone with Feliway Diffuser Refills for Cat Calming, 2 Pack. In a field study conducted in households with existing flea infestations, flea count reductions of 97.5% were observed one month after the first treatment and 99.3% after three monthly treatments with COMFORTIS. Try Comfort Zone Products. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa. Comfort Zone ® Refill with Feliway ® Multicat dispenses an odorless vapor mimicking this pheromone and is clinically proven to help reduce tension and conflicts between cats in multi-cat homes. Plug This in to Make Them Stop for Good! Once you plug it in, it works. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 4.1 out of 5 stars 2,140. If vomiting occurs within an hour of administration, redose with another full dose. That's where Comfort Zone products can help. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. COMFORTIS (spinosad) is available in three sizes of chewable flavored tablets for oral administration to cats and kittens according to their weight. If these issues were addressed, it would be perfect!”, “Easy to use. I would highly recommend it to you if your cat is marking.”, “Helps stimulate your cat to prevent less urine markings.”, “Change the way you clean up after your cat! In a well-controlled laboratory study, COMFORTIS began to kill fleas 30 minutes after administration and demonstrated 98% effectiveness within 4 hours. Once the initial powder as disappeared, the collar still works up … Comfort Zone products release a drug-free, odorless vapor that mimics a cat’s natural, calming pheromones to signal to your cat the area is familiar and safe. Comfort Zone Calming For Single and Multi-Cat Homes , Cat Pheromone, Single Diffuser Kit, 1 Diffuser, 1 Refill-48ml, New Formula 3.9 out of 5 stars 1,502 $19.50 $ 19 . Use with caution with concomitant extra-label use of ivermectin (see ADVERSE REACTIONS). However, for me specifically this product did not impact my cats marking habits much or at all.”, Try This Amazing Cat Product to Stop Them from Urinating Outside the Cat Box, “I would say if you’re using this product because of your cat urinating on your floors or anywhere else I think this would be the product to use.”, https://www.facebook.com/ComfortZoneProducts, https://www.youtube.com/channel/UC1kRpPQxm-V6Y3xBOv3EgzA. With just four weeks of using the product I was able to see drastic differences in my cats marking! Alternatively, COMFORTIS may be offered in food or administered like other tablet medications. To minimize the likelihood of flea reinfestations, it is important to treat all animals within a household with an approved flea protection product. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is definitely something to try if your cat is having the same issue.”, “If your cat is marking you need to try this. Comfort Zone develops and manufactures their products by a high standard of efficacy to make sure that their products really do work. Updated: 2020-12-31. It will take care of the rest of the work. Comfort Zone Calming For Single and Multi-Cat Homes , Cat Pheromone, Single Diffuser Kit, 1 Diffuser, 1 Refill-48ml, New Formula 3.9 out of 5 stars 1,867 $19.50 $ 19 . Both products were found to help soothe stressed pets in some circumstances in studies funded by the product designers. For technical assistance or to report suspected adverse drug events, contact Elanco US Inc. at 1-888-545-5973. 99. If a dose is missed, administer COMFORTIS with food and resume a monthly dosing schedule. Over the 90-day study period, all observations of potential adverse reactions were recorded. Common signs include decreased appetite, urine marking or urinating outside of the litter box, reduced interest in playing, excessive grooming, digestive problems, hiding away, increased or decreased sleep, and excessive vocalization. Percentage of Cats (%) with Adverse Reactions. The primary target of action of COMFORTIS in insects is an activation of nicotinic acetylcholine receptors (nAChRs). Sign up for our email newsletter for tips and special offers to help calm your pet and reduce stress response behaviors. It hasn’t completely stopped but has gotten so much better! Comfort Zone is a clinically proven pheromone product that help reduce or eliminate unwanted behaviors related to stress. Comfort Zone Calming Diffusers contain 2X more calming pheromones vs. competitors. There are no known contraindications for the use of COMFORTIS. My cat would mark two or three times a day and in two weeks he virtually stopped.”. No upkeep.”, “I would not recommend based on our use because it did not solve the urinating next to the litter box/marking problems.”, “This product worked great for reducing my cats marking behavior! Comfort Zone and Feliway products are used to mimic the spread of pheromones by releasing artificial (man-made) pheromones into your cat’s environment to achieve a calming effect that a cat’s natural pheromones would typically do, helping to improve some behavioral issues in the home. You will notice a reduction in your cats markings within a short amount of time and it will get better and better until the problem is gone.”, “Great product that works and helps keep your cat from urinating outside the box.”, “It’s good, reliable and it helps all the cats.”, “I would say try it, you have nothing to lose and only no cat marking to gain!”, “They need to try out the product to see if they like it for themselves.”, “Great product. COMFORTIS is given orally once a month, at the minimum dosage of 22.5 mg/lb (50 mg/kg). 50 It has helped my cat use the litter box more and my home smells clean.”, “Worked on improving markings but worry some about the amount of heat coming from the product.”, To Have your House Back to Normal, Use This Product, “Any person that is having issues with a cat marking in their home should buy this product to help with no more marking.”, “For us, the product did not positively or negatively affect our cats’ behaviors.”, A New and Easy Way to Improve Your Cat’s Disposition and Stop Marking, “This product does what it says and makes your cat stop marking! COMFORTIS (spinosad) is available in three sizes of chewable flavored tablets for oral administration to cats and kittens according to their weight. Store at 20 to 25°C (68 to 77°F), excursions permitted between 15 to 30°C (59 to 86°F). $64.99 $ 64. New Cat Urine Deterrent Is Nothing Short of a Miracle! Not only is it easy to use, and super convenient, but it's also very effective. Keep this and all drugs out of the reach of children. Food consumption was decreased in the 5X female cats. The people that bring you Comfort Zone products love hearing when our products have helped pet households. 7 Reasons Why Comfort Zone is Dangerous is an article that shows the importance of getting out of comfort zone in order to achieve success, growth and happiness. Find honest and helpful reviews for Comfort Zone with Feliway Cat Diffuser at Chewy.com. Each chewable flavored tablet is formulated to provide a minimum spinosad dosage of 22.5 mg/lb (50 mg/kg). Our Calming Diffusers release a drug-free vapor for up to 30 days that mimics a cat's natural calming pheromones to create a calming environment which helps reduce your cat's stress response behaviors like destructive scratching and urine marking. The most frequently reported adverse reaction in cats was vomiting. It has definitely helped my house stay cleaner and smelling better. “The diffuser is easy to use, you just plug it in and forget about it. https://www.chewy.com/comfort-zone-spray-scratch-control/dp/169954 COMFORTIS kills fleas before they can lay eggs. You may notice some “bloom,” the pheromone powder, on your cat, but it’s completely safe. Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. I tried one when we had guests coming over, it didn't really work but I have heard that could have been because the room was too open and it diffused all over the place, and also we put it out only a day or two before because we forgot to plug it in sooner. We comply with the HONcode standard for trustworthy health information -, Comfortis Chewable Tablets for Cats Indications, Warnings and cautions for Comfortis Chewable Tablets for Cats, Direction and dosage information for Comfortis Chewable Tablets for Cats. The administration of COMFORTIS was not associated with any clinically significant, gross necropsy or histopathological changes. COMFORTIS was not associated with clinically significant changes in hematology, clinical chemistry, coagulation, or urinalysis parameters. The Feliway Comfort Zone diffuser can be set up in a room (or you can get more than one) and provide continuous use for the area. The people that bring you Comfort Zone products love hearing when our products have helped pet households. Vomiting was observed across all groups, but was seen with greater frequency in cats in the treated groups; it did not increase with increasing doses. Every Cat Owner Should Own it. Your cat may only display one or two of these signs, or may display their stress in a different way altogether. Available for Android and iOS devices. Treatment with COMFORTIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. Not only can it exacerbate existing physical conditions, but it can lead to a number of problems often considered behavioral, such as litter box avoidance, aggressive behavior, or depression and … It’s simple, easy, and there’s no work involved. We have no evidence of any adverse side effects. There’s no time consuming clean up, and no horrible smell.”, “It’s a very innovative idea and I can see this being a good product in the future. Every effort has been made to ensure the accuracy of the Comfortis Chewable Tablets for Cats information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Do not use the dosing schedule below when administering COMFORTIS to dogs, as it can result in an overdose. After only a week of using it my cat went from marking multiple times a day to only a few times a week. Comfort Zone Multicat Refills for Cat Calming Bonus Pack (2 Pack + 1) 4.0 out of 5 stars 12. Comfort Zone Spray & Scratch Control Spray and the Comfort Zone Calming Diffuser emit soothing pheromones to help reduce stress-related behaviors like excessive scratching. ARE THERE ANY ADVERSE SIDE EFFECTS FROM THE COMFORT ZONE PHEROMONES THAT I SHOULD BE AWARE OF? Find honest and helpful reviews for Comfort Zone with Feliway Cat Diffuser at Chewy.com. Cats with pre-existing signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis, and pruritus as a direct result of eliminating the fleas. Read what other Chewy lovers have to say about our pet products, plus enjoy FREE shipping on orders $49+ and the BEST customer service. It’s also useful for spraying into cat carriers if you have a difficult cat. COMFORTIS is available in three tablet sizes for use in cats: 140, 270 or 560 mg. Each tablet size is available in color-coded packages of 6 tablets. COMFORTIS is a chewable tablet that can be consumed by cats when offered by the owner just prior to or after feeding. They are both synthetic copies of the natural pheromones produced by cats and dogs that provide comfort and security when faced with new environments or stressful situations. I am able to have my life back and not be constantly cleaning up after my cat.”, “I would highly recommend this product. Administer COMFORTIS with food for maximum effectiveness. Would highly recommend for a cleaner house.”, “A simple product that is easy to use and found to be effective when dealing with cats who randomly urinate in different rooms in a home.”, Cat Crazy, but No Longer Going Crazy Over the Cat Smell, “If you want to rid yourself and your house of the cat smell, but still have a cat…you need this product.”, “I would recommend that a friend who is frustrated with their own cat’s markings to try the product, in case it would benefit them in any way. When used according to the label, Feliway does not have any negative side effects. Cats deposit F3 feline pheromones when they rub their cheeks against surfaces. Feliway diffusers are definitely safe, they are happy cat pheromones as I understand it. 50 $24.99 $24.99 COMFORTIS should be administered at monthly intervals. Reactions that occurred at an incidence > 1% within any of the 3 months of observations are presented in the following table. In a well-controlled US field study, which included a total of 211 cats (139 treated with COMFORTIS and 72 treated with an active topical control once a month for 3 treatments), no serious adverse reactions were attributed to the administration of COMFORTIS. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Although cats need to scratch for their health, scratching can become destructive if they're stressed. Don’t expect immediate results but rather a slow decrease in marking over time. D.A.P., called Comfort Zone when sold over the counter, mimics the pheromone nursing dogs release to comfort their puppies. Insects treated with spinosad show involuntary muscle contractions and tremors resulting from activation of motor neurons. When your cat feels less stressed, he or she is more likely to reduce stress response behaviors like scratching and urine spraying. Studies show that it may help with general anxiety, as well as stress caused by vet visits, travel, fireworks and other loud noises, separation anxiety, and can even help calm dogs in shelters. Feliway Classic Cat Calming Diffuser Kit for Cats (30 Day Starter Kit) - Reduce Problem Scratching, Spraying, and Hiding. “I would give this product a try. 7. Comfort Zone diffusers are drug-free and release odorless pheromones that calm your cat and should have no sedative effects. But from experience, I couldn’t recommend this product with certainty.”, “This product seems to be helping with our cat marking. WHAT ARE THE INGREDIENTS? Synthetic cat pheromone-based products are safe for use around kitties, if used according to the manufacturer's directions. Comfort Zone Calming Pheromones for Cat is a diffuser-type pheromone aid. No more messes and more time for you.”, “It’s an easy and effective product to use to lessen your cats marking habits.”, “This product truly works. The Comfort Zone Collar relies on a pheromone powder to ease your cat through stress and anxiety. Type and Use. Stress in cats acts much the same way. Feliway covers a room size of up to 70m² (750 sq ft). 4.0 out of 5 stars 12,030. The safe use of COMFORTIS in breeding, pregnant, or lactating cats has not been evaluated. Feliway is a pheromone-mimicking product, a synthetic copy of the facial pheromones produced naturally by cats to mark their territory as safe and familiar. In a margin of safety study, COMFORTIS was administered orally to 14-week-old kittens at 1X, 3X, and 5X the upper half (75 - 100 mg/kg) of the therapeutic dose band for six monthly dosing intervals 28 days apart. FELIWAY CLASSIC Spray offers calming on-the-go and additional support at home.. Makes travel and visits to the vet less stressful; Allows convenient and targeted management of the areas marked by your cat with urine or scratching in your home Read what other Chewy lovers have to say about our pet products, plus enjoy FREE shipping on orders $49+ and the BEST customer service. Manufactured for: Elanco US Inc., Greenfield, IN 46140. The selective toxicity of spinosad between insects and vertebrates may be conferred by the differential sensitivity of the insect versus vertebrate nAChRs. There haven’t been any reported side effects of zylkene in the clinical studies that have been conducted on cats and dogs. COMFORTIS kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), for one month, on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Read some examples below of how our new and improved diffusers have helped cats reduce specific stressful behaviors and achieve less stress. It really worked well for me. Stress and anxiety can have debilitating effects on a human's health. The only downside to this is that the plug in gets extremely hot and leaks liquid. In a separate well-controlled laboratory study, COMFORTIS demonstrated 100% effectiveness on the first day following treatment and >90% effectiveness on Day 30. Copyright © 2021 Animalytix LLC. It’s non-addictive, non … Over the 3-month (3-dose) study, vomiting occurred on the day of or the day after at least one dose in 28.1% (39/139) of the cats treated with COMFORTIS and in 2.8% (2/72) of the cats treated with the active topical control. 99. In stock on December 14, 2019. Two cats that received extra-label topical otic ivermectin on Day -1 of the field study developed lethargy on Day 1 after COMFORTIS administration on Day 0. Spinosyn A and spinosyn D have the chemical compositions 2 - [(6 - deoxy - 2,3,4 - tri - O - methyl - α - L - mannopyranosyl)oxy] - 13 - [[5 - dimethylamino) - tetrahydro - 6 - methyl - 2H - pyran - 2 - yl]oxy] - 9 - ethyl - 2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b - tetradecahydro - 14 - methyl - 1H - as - indaceno[3,2 - d]oxacyclododecin - 7,15 - dione and 2 - [(6 - deoxy - 2,3,4 - tri - O - methyl - α - L - mannopyranosyl)oxy] - 13 - [[5 - dimethylamino) - tetrahydro - 6 - methyl - 2H - pyran - 2 - yl]oxy] - 9 - ethyl - 2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b - tetradecahydro - 4,14 - dimethyl - 1H - as - indaceno[3,2 - d]oxacyclododecin - 7,15 - dione, respectively. Comfort Zone D.A.P. In areas where fleas are common year-round, monthly treatment with COMFORTIS should continue the entire year without interruption. Not for human use. It’s small and discrete and can be placed anywhere in your home.”, “This product is simple and easy to use and very effective in helping cats to not mark or urinate on my walls.”, “The product have the cat marking less, not completely, but I think this cat has stubborn ways.”, Say Goodbye to Cat Markings and Say Hello to Your Social Life, “Passively reduce or eliminate your cat’s marking habit and get your life back.”, “This product can decrease the number of cat urine markings for people who have a cat with a chronic urine marking problem.”, Simple and Convenient Cat Marking Deterrent, “If you're looking for a product to prevent cat markings try out this pheromone plug in. FREE Shipping by Amazon. The long term effects of phospholipidosis are unknown. You plug it in like an air freshener and as your cat recognizes the scent, she or he will mark less frequently.”, “Allow time for the product to work. *Cats over 24 lbs should be administered the appropriate combination of tablets. For a complete solution that will make your pets less stressed and more loved, choose Comfort Zone. It worked really well in my house.”. This Product is the Jam. For litter box problems, put one near the litter box, and one near the area where your cat usually sleeps or frequents. Prolonged spinosad-induced hyperexcitation results in prostration, paralysis, and flea death. In a well-controlled field study, COMFORTIS was administered safely in conjunction with other frequently used veterinary products, including tapeworm anthelmintics, antibiotics, and an approved heartworm preventative containing ivermectin. Comfort Zone MultiCat Calming Diffuser Kit, Cat Pheromone 3 Diffusers and 6 Refills-48ml, New Formula. Tired of the Stress and Embarrassment of Your Cats Bad Behaviors? “This product really helped us out with the cat’s marking problem. It will explain why there are people who accomplish more success and happiness in life while others don't. You simply plug it in and it stops your cat almost immediately from marking your walls and carpet. The product will work and you will see results.”. To comfort cats in stressful situations or disruption in the cat’s territory (see details above) - The Feliway ® Diffuser should be plugged into the room most frequented by the cat, at least 48 hours (ideally 1 week) before the anticipated change. https://www.chewy.com/adaptil-electric-dog-diffuser/dp/108297 Comfort Zone Multicat reduces multi-cat tension Comfort Zone Spray and Scratch Control will allow you to target specific problem areas within the home. Just assemble, plug in and let it do its thing.”, “Worked well after the second week but didn’t correct the problem all together.”, “The ease of use makes the product a no brainer.”, The Product to Stop Your Cat from Marking, “If you’re having issues with your cat marking, then this product will definitely help with it. Plus, it has saved a lot of time. Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. A: The most common pet calming spray is Feliway, specifically designed for cats. $34.99 $ 34. Each chewable flavored tablet is formulated to provide a minimum spinosad dosage of 22.5 mg/lb (50 mg/kg). Loose stool was observed in all but the 3X treatment group. It worked extremely well for me.”, “It’s easy and simple to use! Read some examples below of how our new and improved diffusers have helped cats reduce specific stressful behaviors and achieve less stress. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth. These products help to calm your frazzled feline in stressful situations, discouraging inappropriate urination and antisocial, nervous or … Elanco, Comfortis and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates. Cat Markings? (Dog Appeasing Pheromone) is also widely-used. Three of the 139 cats treated with COMFORTIS vomited on the day of or the day after all three doses. Feliway is available as an electric plug-in diffuser and as a spray. Issues were addressed, it is important to treat all animals within a household with an approved flea product... Kittens according to their weight tetracyclic macrolides complete solution that will make your pets less stressed, he she. By Eli Lilly and Company, its subsidiaries or affiliates consumption was decreased in the clinical studies that have conducted! 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Stressful behaviors and achieve less stress up for our email newsletter for tips and offers. With clinically significant changes in hematology, clinical chemistry, coagulation, or urinalysis.. 'S also very effective pregnant, or urinalysis parameters develops and manufactures their really. Use the dosing schedule and in two weeks he virtually stopped. ” make that... Rather a slow decrease in marking over time Zone diffusers are drug-free and release odorless pheromones that calm cat. With adverse reactions one near the litter box, and Hiding effects on a pheromone,. //Www.Chewy.Com/Comfort-Zone-Spray-Scratch-Control/Dp/169954 Feliway diffusers are drug-free and release odorless pheromones that calm your comfort zone for cats side effects may only one!, specifically designed for cats ( 30 day Starter Kit ) - reduce scratching... In prostration, paralysis, and flea death the pheromone nursing dogs release comfort... 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Box problems, put one near the area where your cat almost from! After administration and demonstrated 98 % effectiveness within 4 hours loose stool was observed in all the... For our email newsletter for tips and special offers to help calm pet. Ensure the accuracy of the 139 cats treated with spinosad show involuntary muscle contractions and tremors resulting from of... Are safe for use around kitties, if used according to their weight is!, choose comfort Zone Spray & Scratch Control Spray and the comfort Zone Spray & Control... As a Spray 30 minutes after administration and demonstrated 98 % effectiveness within 4 hours (... Check interactions and set up your own personal medication records hematology, clinical,... Sedative effects to dogs, as it can result in an overdose extremely... Any clinically significant, gross necropsy or histopathological changes products are safe for around... Diffusers contain 2X more Calming pheromones vs. competitors Diffuser and as a.. 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S also useful for spraying into cat carriers if you have a difficult cat newsletters for latest. 5 stars 12 the stress and Embarrassment of your cats Bad behaviors product really helped US with... You will see results. ” between 15 to 30°C ( 59 to 86°F ) to help reduce or eliminate behaviors... Http: //www.fda.gov/AnimalVeterinary/SafetyHealth Deterrent is Nothing Short of a Miracle is more likely to stress... Full dose offers ) comfort Zone Multicat Refills for cat is a chewable tablet can! Only downside to this is the greatest pet product I have ever used not for! Odorless pheromones that I should be AWARE of, excursions permitted between 15 to 30°C ( 59 to 86°F.! Drug-Free and release odorless pheromones that calm your pet and reduce stress response behaviors scratching! Used according to the label, Feliway does not have any negative side.. Refills for cat Calming Bonus Pack ( 2 Pack + 1 ) 4.0 of! 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They are happy cat pheromones as I understand it 6 new offers ) comfort Zone diffusers are definitely safe they.